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Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

Identifieur interne : 002904 ( Main/Exploration ); précédent : 002903; suivant : 002905

Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance

Auteurs : Marcin Kolaczkowski [Belgique] ; André Goffeau [Belgique]

Source :

RBID : ISTEX:88A2AB5D5FC63601A901D6C94247DB3CA33733B0

English descriptors

Abstract

Abstract: Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.

Url:
DOI: 10.1016/S0163-7258(97)00094-6


Affiliations:


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Le document en format XML

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<term>Active efflux</term>
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<term>Annu</term>
<term>Antibiotic</term>
<term>Anticancer</term>
<term>Anticancer drugs</term>
<term>Antifungal</term>
<term>Antimicrob</term>
<term>Apoptosis</term>
<term>Assay</term>
<term>Aureus</term>
<term>Awasthi</term>
<term>Azole</term>
<term>Balzi</term>
<term>Biochem</term>
<term>Biol</term>
<term>Biotechnol</term>
<term>Borst</term>
<term>Bossche</term>
<term>Broad specificity</term>
<term>Cancer cells</term>
<term>Cancer chemotherapy</term>
<term>Candida</term>
<term>Cassette</term>
<term>Cdrl</term>
<term>Cell lines</term>
<term>Cereoisiae</term>
<term>Cerevisiae</term>
<term>Chem</term>
<term>Chemother</term>
<term>Chemotherapy</term>
<term>Chloramphenicol</term>
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<term>Different combinations</term>
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<term>Efflux</term>
<term>Encoding</term>
<term>Escherichia</term>
<term>Extracellular space</term>
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<term>Febs lett</term>
<term>Fungi</term>
<term>Gene</term>
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<term>Gene therapy</term>
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<term>Glutathione conjugates</term>
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<term>Kuchler</term>
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<term>Lipid phase</term>
<term>Major facilitator superfamily</term>
<term>Mdrl</term>
<term>Mediates resistance</term>
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<term>Membrane vesicles</term>
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<term>Microorganism</term>
<term>Molecular mechanisms</term>
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<term>Multidrug resistance</term>
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<term>Multidrug resistance protein</term>
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<term>Multidrug transporter</term>
<term>Multidrug transporters</term>
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<term>Mutant</term>
<term>Mutation</term>
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<term>Nikaido</term>
<term>Nitiss</term>
<term>Ouelette</term>
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<term>Oxidized glutathione</term>
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<term>Superfamily</term>
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<div type="abstract" xml:lang="en">Abstract: Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.</div>
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