Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance
Identifieur interne : 002904 ( Main/Exploration ); précédent : 002903; suivant : 002905Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance
Auteurs : Marcin Kolaczkowski [Belgique] ; André Goffeau [Belgique]Source :
- Pharmacology and Therapeutics [ 0163-7258 ] ; 1997.
English descriptors
- Teeft :
- Acad, Active efflux, Acute myeloid leukemia, Agents chemother, Annu, Antibiotic, Anticancer, Anticancer drugs, Antifungal, Antimicrob, Apoptosis, Assay, Aureus, Awasthi, Azole, Balzi, Biochem, Biol, Biotechnol, Borst, Bossche, Broad specificity, Cancer cells, Cancer chemotherapy, Candida, Cassette, Cdrl, Cell lines, Cereoisiae, Cerevisiae, Chem, Chemother, Chemotherapy, Chloramphenicol, Chloroquine, Chloroquine resistance, Clin, Clinical resistance, Conductance, Cowman, Curr, Cystic, Cystic fibrosis transmembrane conductance regulator, Cytotoxic, Daunorubicin, Deeley, Different combinations, Dihydrofolate reductase, Doxorubicin, Drug resistance, Drug resistance mechanisms, Drug transport, Efflux, Encoding, Escherichia, Extracellular space, Feb, Febs lett, Fungi, Gene, Gene encoding, Gene therapy, Genet, Glutathione, Glutathione conjugates, Goffeau, Gottesman, Gros, Homologue, Homologues, Hypersensitivity, Inhibitor, Intracellular, Intracellular accumulation, Kolaczkowski, Kuchler, Large variety, Lett, Lipid, Lipid phase, Major facilitator superfamily, Mdrl, Mediates resistance, Membrane, Membrane vesicles, Microbial, Microorganism, Molecular mechanisms, Multidrug, Multidrug resistance, Multidrug resistance phenotype, Multidrug resistance protein, Multidrug transport, Multidrug transporter, Multidrug transporters, Multiple resistance, Mutant, Mutation, Natl, Nikaido, Nitiss, Ouelette, Oxidative stress, Oxidized glutathione, Parasitic protozoa, Parasitol, Pastan, Pathogen, Paulsen, Pdr5p, Pdrsp, Peptide, Permeability, Pfmdrl, Pfmdrl gene, Pghl, Pharmacol, Phenotype, Plasmid, Plasmodium, Plasmodium fakiparum, Plasmodium falciparum, Pleiotropic, Pleiotropic drug resistance, Proc, Proton motive force, Pseudomonas aeruginosa, Receptor, Regulator, Resis, Resistance, Ruetz, Saccharomyces, Saccharomyces cereoisiae, Saccharomyces cerevisiae, Sanglard, Scheffer, Schuldiner, Secretory vesicles, Snq2p, Specificity profiles, Staphylococcus aureus, Steroid, Substrate specificity, Superfamily, Tance, Target enzyme, Tetracycline, Topoisomerase, Trans, Transmembrane, Transporter, Transposon, Trends biotechnol, Vanden, Vanden bossche, Vesicle, Vinblastine, Vincristine, Yeast, Yeast cells, Yeast saccharomyces cerevisiae.
Abstract
Abstract: Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.
Url:
DOI: 10.1016/S0163-7258(97)00094-6
Affiliations:
- Belgique
- Province du Brabant wallon, Région wallonne
- Louvain-la-Neuve
- Université catholique de Louvain
Links toward previous steps (curation, corpus...)
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- to stream Istex, to step Curation: 000D62
- to stream Istex, to step Checkpoint: 001697
- to stream Main, to step Merge: 002953
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Le document en format XML
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<term>Annu</term>
<term>Antibiotic</term>
<term>Anticancer</term>
<term>Anticancer drugs</term>
<term>Antifungal</term>
<term>Antimicrob</term>
<term>Apoptosis</term>
<term>Assay</term>
<term>Aureus</term>
<term>Awasthi</term>
<term>Azole</term>
<term>Balzi</term>
<term>Biochem</term>
<term>Biol</term>
<term>Biotechnol</term>
<term>Borst</term>
<term>Bossche</term>
<term>Broad specificity</term>
<term>Cancer cells</term>
<term>Cancer chemotherapy</term>
<term>Candida</term>
<term>Cassette</term>
<term>Cdrl</term>
<term>Cell lines</term>
<term>Cereoisiae</term>
<term>Cerevisiae</term>
<term>Chem</term>
<term>Chemother</term>
<term>Chemotherapy</term>
<term>Chloramphenicol</term>
<term>Chloroquine</term>
<term>Chloroquine resistance</term>
<term>Clin</term>
<term>Clinical resistance</term>
<term>Conductance</term>
<term>Cowman</term>
<term>Curr</term>
<term>Cystic</term>
<term>Cystic fibrosis transmembrane conductance regulator</term>
<term>Cytotoxic</term>
<term>Daunorubicin</term>
<term>Deeley</term>
<term>Different combinations</term>
<term>Dihydrofolate reductase</term>
<term>Doxorubicin</term>
<term>Drug resistance</term>
<term>Drug resistance mechanisms</term>
<term>Drug transport</term>
<term>Efflux</term>
<term>Encoding</term>
<term>Escherichia</term>
<term>Extracellular space</term>
<term>Feb</term>
<term>Febs lett</term>
<term>Fungi</term>
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<term>Gene encoding</term>
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<term>Glutathione</term>
<term>Glutathione conjugates</term>
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<term>Gottesman</term>
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<term>Homologue</term>
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<term>Lett</term>
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<term>Lipid phase</term>
<term>Major facilitator superfamily</term>
<term>Mdrl</term>
<term>Mediates resistance</term>
<term>Membrane</term>
<term>Membrane vesicles</term>
<term>Microbial</term>
<term>Microorganism</term>
<term>Molecular mechanisms</term>
<term>Multidrug</term>
<term>Multidrug resistance</term>
<term>Multidrug resistance phenotype</term>
<term>Multidrug resistance protein</term>
<term>Multidrug transport</term>
<term>Multidrug transporter</term>
<term>Multidrug transporters</term>
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<term>Nikaido</term>
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<term>Ouelette</term>
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<term>Permeability</term>
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<term>Pfmdrl gene</term>
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<term>Resistance</term>
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<term>Saccharomyces cereoisiae</term>
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<term>Tance</term>
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<term>Tetracycline</term>
<term>Topoisomerase</term>
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<term>Transmembrane</term>
<term>Transporter</term>
<term>Transposon</term>
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<term>Vanden bossche</term>
<term>Vesicle</term>
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<front><div type="abstract" xml:lang="en">Abstract: Mankind is faced by the increasing emergence of resistant pathogens, including cancer cells. An overview of the different strategies adopted by a variety of cells to evade chemotherapy is presented, with a focus on the mechanisms of multidrug transport. In particular, we analyze the yeast network for pleiotropic drug resistance and assess the potentiality of this system for further understanding of the mechanism of broad specificity and for development of novel practical applications.</div>
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